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KMID : 0350519930460010331
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Journal of Catholic Medical College
1993 Volume.46 No. 1 p.331 ~ p.343
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Clinical Study of the Head and Neck Squamous Neoplasms and Detection of hunan Papilloma Virus DNA Using In Situ Hybridization
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Abstract
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Squamous papilloma and squamous cell carcinoma are the most common neoplasm of the head and neck. Multiple etiologic factors have been considered in these neoplasms. In the recent advances in the fields of molecular biology, it has been reported that some types of human papillomavirus (HPV) may be closely related to oncogenesis of squamous cell neoplasm in the genitourinary tract, but their role of oncogenesis and prevalence in the head and neck squamous neoplasms have not been well established.
Clinical study and in situ hybridization using biotinylated HPV DNA probes were performed to find out the relationship between HPV and the head and neck squamous neoplasms.
@ES The reslts were as follows :
@EN 1. Among 48 cases of squamous papilloma the most frequently involved organ was larynx(17 cases, 35.4%), and then nasal cavity(14 cases, 29.2%), oropharynx(9 cases, 18.8%), oral cavity(7 cases, 14.6%). And hypopharynx(1 cases, 2.1%) in the decreasing
orders. Amog 43 cases of squamous cell carcinomas, larynx(19 cases, 44.2%) was the most frequently involved organ and nasopharynx(9 cases, 0.9%), oropharyns(6 cases, 14.0%), nasal cavity(5 cases, 11.6%), oral cavity(3 cases, 7.0%), and hypopharynx(1
case, 2.3%) in the decreasing orders.
2. Mean age for squamous papillomas was 40.0 and for squamous cell carcinomas 55.6. There were 6 cases(12.5%) of pediatric patients in the squamous papilloma. Male to female sex ratio of squamous papilloma was 2.7 : 1 and that of squamous cell carcinoma was 6.2 : 1.
3. Fifteen cases(31.3%) of the squamous papillomas and 12 cases(27.9%) of the squamous cell carcinomas had multiple lesions. Among the squamous papilloma patients, 3 cases(50.0%) of the pediatric patients and 12 cases(28.6%) of the adult patient
had multiple squamous papillomas.
4. The most common chief complaints depending upon the location of the tumors were hoarseness in the larynx, nasal stuffiness in the nasal cavity, tumor mass in the oral cavity, sore throat and tumor sensation in the oropharynx, hearing impairment and
epistaxis in the nasopharynx, and hoarseness and neck mass in the hypopharynx.
5. HPV-6/11 DNA was detected n 41.7% of the squamous papillomas : 70.6% of laryngeal tumor, 28.6% of oral cavity and 7.1% of nasal cavity. It was not detected in the squamous cell carcinomas. HPV-16/18 DNA was detected in only one laryngeal squamous
cell carcinoma. No HPV-31/33/35 DNA was detected in all head and neck squamous neoplasms.
Above results suggest that HPV-6/11 infection may be closely associated with the development of squamous papillomas in the various anatomic sites of the head and neck, but the relationship between HPV-16/18 and laryngeal squamous cell carcinoma will
have to be elucidated by further study.
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